AmBisome® treatment of murine cutaneous leishmaniasis: relation between skin pharmacokinetics and efficacy
نویسندگان
چکیده
3 Gert-Jan Wijnant, Katrien Van Bocxlaer, Vanessa Yardley, Andy Harris, Sudaxshina 4 Murdan and Simon L. Croft* 5 6 1. Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London 7 School of Hygiene and Tropical Medicine, London, United Kingdom 8 2. Department of Pharmaceutics, UCL School of Pharmacy, London, United Kingdom. 9 3. Pharmidex Pharmaceutical Services Ltd, 3 floor, Hanover Street, London W1S 1YH, UK 10 11 Corresponding author [email protected]. 12
منابع مشابه
The efficacy of hydro alcoholic extract of Seidlitzia rosmarinus on experimental zoonotic cutaneous leishmaniasis lesions in murine model
Objective: Leishmaniasis is one of the most important parasitic infectious diseases in the world. Since last century, many efforts have been made to control and treat the disease, but appropriate vaccines, pesticides and medicines are not available or even eligible. The purpose of this study was to evaluate the effect of hydro-alcoholic extract of Seidlitzia rosmarinus on the lesions of experim...
متن کاملComparison of efficacy of oral Fluconazole with intramuscular Glucantime in patients with acute cutaneous Leishmaniasis
Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues. Objective: Comparison of the efficacy of fluconazole with systemic glucantime in patients with acute cutaneous leishmaniasis in Ghaem hospital in Mashhad in 2002. Patients and Methods: During one year of study, all patients with cutaneous leishmani...
متن کاملThe efficacy of IPL and ammonium lactate 14% versus ammonium lactate alone in the treatment of keratosis pilaris
Background: Keratosis rubra pilaris is a common condition with an estimated percentage of 40% involvement in the population. This condition is inherited as an autosomal dominant trait and more commonly involves patients with dry skin. In the current study, we evaluated the efficacy of intense pulsed light (IPL) plus ammonium lactate versus ammonium lactate alone in the treatmen...
متن کاملEfficacy of combination of topical honey with intralesional injection of Gglucantime in the treatment of acute cutaneous Leishmaniasis
Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we assessed the efficacy of honey in acute CL.Materials and Methods: In a...
متن کاملEfficacy of Paromomycin ointment prepared in Iran (Paromo-U) against cutaneous Leishmaniasis caused by Leishmania major in mouse model
Background: Considering the difficulties, adverse effects and unsuitable response to commonly used drugs; it is essential to find an alternative, particularly local treatment for cutaneous leishmaniasis (CL). Objective: Determination of efficacy of topical paromomycin (Paromo-U ointment) against CL caused by L.major in mouse model. Materials and Methods: Skin lesions were created 1 to 3 months ...
متن کامل